Whole Cell Imaging of Plasmodium Falciparum Blood Stages

Detection of Plasmodium falciparum Directly from Blood Samples Using the Polymerase Chain Reaction

Immunoproteomics of Plasmodium falciparum-infected red blood cell membrane fractions

BACKGROUND The surface of infected red blood cells (iRBCs) has been widely investigated because of the molecular complexity and pathogenesis mechanisms involved. Asymptomatic individuals are important in the field because they can perpetuate transmission as natural reservoirs and present a challenge for diagnosing malaria because of their low levels of circulating parasites. Recent studies of i...

Peripheral Blood Cell Signatures of Plasmodium falciparum Infection during Pregnancy

Sequestration of Plasmodium falciparum-infected erythrocytes in placental intervillous spaces causes inflammation and pathology. Knowledge of the profiles of immune cells associated with the physiopathology of pregnancy-associated malaria (PAM) is scarce. We conducted a longitudinal, prospective study, both in Benin and Tanzania, including ∼1000 pregnant women in each site with systematic follo...

In-vitro activity of primaquine against the asexual blood stages of Plasmodium falciparum.

Primaquine, an 8-aminoquinoline, has been shown to inhibit the development of the hepatic stages (hypnozoites and schizonts), gametocytes, and asexual, intra-erythrocytic forms of malarial parasites (Peters and Robinson, 1987). This triple action is unique among antimalarial drugs. Primaquine is widely used for its anti-hypnozoite action (i.e. to prevent relapses of Plasmodium vivax or P. ovale...

Mechanisms underlying the monocyte-mediated antibody-dependent killing of Plasmodium falciparum asexual blood stages

The relevance of the antibody-dependent cellular inhibition (ADCI) of Plasmodium falciparum to clinical protection has been previously established by in vitro studies of material obtained during passive transfer of protection by immunoglobulin G in humans. We here report further in vitro investigations aimed at elucidating the mechanisms underlying this ADCI effect. Results obtained so far sugg...